Thank you for following up with this man’s case here. A couple thoughts here on what may be going on, and how to proceed with it. It may be that he, for some reason, is having a reaction to the supplement itself and that another antiviral agent is better for him. As you likely have seen in some of the more chronic and depleted clients you have worked with, people can be sensitive or have an adverse reaction to anything – and the more toxic and depleted the body is, the more likely they have reactions in general. On this line of thought, it may not be the humic acid, but also may be his body’s response to the “die-off” or immune system activation. In many of these very, very sensitive people, I have often needed to start with even trace amounts (drops or a pinch) of therapeutic substances, including homeopathics.
Strategies I would consider with this man include building up his body before trying to use antiviral agents, or using an alternate antimicrobial agent. One thing which may be helpful in his case for a variety of reasons is glutathione. Glutathione supports the body’s viral response, and is often depleted in settings of autoimmunity. It is a very important antioxidant for the body’s processes of detoxification, and when deficient one may develop additional symptoms of immune imbalance and toxicity. This may have been discussed to some regard in our previous dialog, however if you are not using a format such as acetyl-glutathione which has been shown to deliver into the cells of the body, it may not be adequate.
Cai J, et al. Inhibition of influenza infection by glutathione. Free Radic Biol Med. 2003 Apr 1;34(7):928-36. https://tinyurl.com/y8yoxktl
Palamara AT, et al. Evidence for antiviral activity of glutathione: in vitro inhibition of herpes simplex virus type 1 replication. Antiviral Res. 1995 Jun;27(3):237-53. https://tinyurl.com/y9ncp3gf
Peterson JD, et al. Glutathione levels in antigen-presenting cells modulate Th1 versus Th2 response patterns. Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3071-6. https://tinyurl.com/y7spo2ju
Lactoferrin, a glycoprotein found in milk and at much higher concentrations in colostrum, has long been recognized for the role it plays in protecting infants from infection as well as supporting normal immune system function. It has been shown to have antimicrobial activity against parasites, bacteria, fungi, and viruses. Lactoferrin has been shown to have an inhibitory effect on bacterial biofilms as well.
Siqueiros-Cendón T, et al. Immunomodulatory effects of lactoferrin. Acta Pharmacol Sin. 2014 May;35(5):557-66. https://tinyurl.com/y9mxkwbp
Moreno-Expósito L, et al. Multifunctional capacity and therapeutic potential of lactoferrin. Life Sci. 2018 Feb 15;195:61-64. https://tinyurl.com/y8zhca6g
Lactoferrin’s immunomodulating effects support symptom reduction and an improved systemic response. Lactoferrin has been shown to neutralize endotoxin, also directly inhibiting the endotoxin-induced immune system response, both of which contribute to the “die-off” reaction. Lactoferrin has also been shown in several studies to decrease levels of TNF-α. In animal models, the administration of supplemental lactoferrin prior to endotoxin shock dramatically reduced mortality and increased overall wellness.
Zhang GH, et al. Neutralization of endotoxin in vitro and in vivo by a human lactoferrin-derived peptide. Infect Immun. 1999 Mar;67(3):1353-8. https://tinyurl.com/ybxd9kjf
Elass-Rochard E, et al. Lactoferrin inhibits the endotoxin interaction with CD14 by competition with the lipopolysaccharide-binding protein. Infect Immun. 1998 Feb;66(2):486-91. https://tinyurl.com/ydz7z78x
Drago-Serrano ME, et al. Lactoferrin: Balancing Ups and Downs of Inflammation Due to Microbial Infections. Int J Mol Sci. 2017 Mar 1;18(3). https://tinyurl.com/yclyeap4
Lee WJ, et al. The protective effects of lactoferrin feeding against endotoxin lethal shock in germfree piglets. Infect Immun. 1998 Apr;66(4):1421-6. https://tinyurl.com/y75qgow9
Lactoferrin in combination with colostrum may be an appropriate combination for him, as the addition of colostrum helps to decrease intestinal permeability which may be contributing to his systemic immune response. In animal models of autoimmune arthritis, local treatment with lactoferrin has been shown to have a positive outcome, reducing joint inflammation up to 71% of that a steroid did.
Guillen C, et al. The effects of local administration of lactoferrin on inflammation in murine autoimmune and infectious arthritis. Arthritis Rheum. 2000 Sep;43(9):2073-80. https://tinyurl.com/yb59bf5f
Hałasa M, et al. Oral Supplementation with Bovine Colostrum Decreases Intestinal Permeability and Stool Concentrations of Zonulin in Athletes. Nutrients. 2017 Apr 8;9(4). pii: E370. https://tinyurl.com/ydbce84y
Playford RJ, et al. Co-administration of the health food supplement, bovine colostrum, reduces the acute non-steroidal anti-inflammatory drug-induced increase in intestinal permeability. Clin Sci (Lond). 2001 Jun;100(6):627-33. http://tinyurl.com/kjv78tw
Herlea V. Antifungal effects of the antimicrobial factors in human milk and colostrum in mixed bacterial and fungal cultures. Rev Ig Bacteriol Virusol Parazitol Epidemiol Pneumoftiziol Bacteriol Virusol Parazitol Epidemiol. 1985 Jan-Mar;30(1):43-8. http://tinyurl.com/pgqmwy7
The following supplements are suggested for you to consider in light of your relevant expertise and understanding of the needs of your client or patient. They may be used in isolation or as part of a multi supplement strategy, but at all times the consideration of their use should be tied into the specific needs of the individual you are responsible for.
Acetyl-Glutathione (ARG): 1 tablet twice daily. http://tinyurl.com/n68cpfy Support for viral response and detoxification.
L-Lysine 500mg (ARG): 2 capsules twice daily. https://tinyurl.com/yclhqt4q Support for viral response.
Laktoferrin With Colostrum (ARG): 1 capsule twice daily. https://tinyurl.com/y7l6gcfq
NT Factor ATP Lipids (ARG): ¼ – ½ teaspoon two times daily. http://tinyurl.com/n7b7sap Phospholipid combination that supports cellular repair.
Please consider these suggestions in light of the other clinical information pertaining to this individual. If you have any more information about the specific problems this individual is experiencing, further refinement of these suggestions may be considered. I hope this information is helpful, and if you have any further questions or information specific to the problems this individual is experiencing, please do provide feedback.
Registered Nutritional Therapist Helen Perks is collaborating with Clinical Education to bring you the first-ever Functional Medicine book club for Practitioners.
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