F with recent diagnosis of MS wrinkled skin on left foot

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Welcome! Forums F with recent diagnosis of MS wrinkled skin on left foot

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    • #1001
      Deborah Walker
      Participant

      I have a client who has been recently diagnosed with MS who is doing very well with the changes given to her with diet and supplements. Except for one aspect, which is that the skin on the left foot is very wrinkled across the top, not the whole foot, just half way up the foot from the toes, and the top of the foot not the underside. It’s as though she has been sat in the bath for an extended timescale, and the foot gets worse in the bath and gets worse when she is tired! I’m stumped because it’s not happening anywhere else on the body, the skin is good everywhere else. Any suggestions or enlightenment would be great.

       

      Posted by Deborah Walker 10.01.18

    • #1002
      Antony Haynes
      Moderator

      Hello Deborah,

      Thank you for presenting this case to us, and congratulations on supporting this patient’s health. It does appear to be out of the ordinary, what you describe. I do not have experience with signs such as these in any patient, and I regularly meet patients with MS. The suggestions presented here are not based on clinical experience with this specific condition and neither are they research or evidence-based. It is hoped that one or more of the suggestions helps address this issue, however.

      It does not appear to be possible or logical to consider that these skin wrinkles are caused by the same thing that wrinkles on the face, for example, which is most often ultraviolet light damage and oxidative stress. In this way, the consideration of antioxidant therapy or collagen, appears pointless.

      Over time, with the ongoing support that this woman is already involved with, it is possible that the wrinkled skin will ameliorate as a reflection of resolving internal and underlying imbalances.

      However, it may be that there is poor nerve supply to the specific location on this woman’s foot, which is resulting in lack of ideal oxygen flow and resulting wrinkles. This could be a part, albeit a curious part, of this woman’s expression of the MS that she has. That the wrinkling is worse when she is tired supports a theory that her nervous system is involved, since the nervous system is readily affected by reduced energy levels.

      B vitamins

      B vitamins are vital for nervous system health in MS and other neurological disorders.

      Nemazannikova N, Mikkelsen K, Stojanovska L, Blatch GL, Apostolopoulos V. Is there a link between vitamin B and multiple sclerosis? Med Chem. 2017 Sep 6. doi: 10.2174/1573406413666170906123857. [Epub ahead of print]. View Abstract

       

      A blood test for B vitamins may be of value, yet at the same time, levels higher than that which correct a deficiency may achieve positive health outcomes. Biolab offer tests for the B vitamins.

      Thiamin

      In this way, both energy and neurological support nutrients may have some impact. Vitamin B1 is vital for nerve transmission and is a nutrient that has long been used and considered for neurological disorders.

      Postepy Hig Med Dosw (Online). 2015 Sep 21;69:1096-106. Bubko I, Gruber BM, Anuszewska EL. [The role of thiamine in neurodegenerative diseases]. [Article in Polish] View Abstract

       

      Biotin

      Biotin has been found to be important for MS patients of a certain type in terms of supporting the healing of the myelin sheath. Whilst this woman may not have relapsing, remitting MS, I have found in the small cohort of patients that some symptoms associated with the nervous system have reduced or resolved after the taking of the biotin supplement.

      Biotin is involved in carboxylase reactions, which is to say that it acts as a catalyst to add carboxyl groups or catalyzes the release of carbon dioxide from the carboxyl group of certain organic acids.

      In other words, biotin is a vitamin acting as a coenzyme for carboxylases involved in key steps of energy metabolism and fatty acids synthesis. Among others, biotin activates acetylCoA carboxylase, a potentially rate-limiting enzyme in myelin synthesis.

      Sedel F, Papeix C, Bellanger A, Touitou V, Lebrun-Frenay C, Galanaud D, Gout O, Lyon-Caen O, Tourbah A. High doses of biotin in chronic progressive multiple sclerosis: a pilot study. Mult Scler Relat Disord. 2015 Mar;4(2):159-69. doi: 10.1016/j.msard.2015.01.005. Epub 2015 Jan 24. View Abstract

      Sedel F, Bernard D, Mock DM, Tourbah A. Targeting demyelination and virtual hypoxia with high-dose biotin as a treatment for progressive multiple sclerosis. Neuropharmacology. 2015 Sep 5. pii: S0028-3908(15)30073-3. doi: 10.1016/j.neuropharm.2015.08.028. [Epub ahead of print] View Full Article

      Shirani A, Okuda DT, Stüve O. Therapeutic Advances and Future Prospects in Progressive Forms of Multiple Sclerosis. Neurotherapeutics. 2016 Jan;13(1):58-69. doi: 10.1007/s13311-015-0409-z. View Abstract

      Peyro Saint Paul L, Debruyne D, Bernard D, Mock DM, Defer GL. Pharmacokinetics and pharmacodynamics of MD1003 (high-dose biotin) in the treatment of progressive multiple sclerosis. Expert Opin Drug Metab Toxicol. 2016 Mar;12(3):327-44. doi: 10.1517/17425255.2016.1136288. Epub 2016 Feb 17. View Abstract

      Sedel F, Bernard D, Mock DM, Tourbah A. Targeting demyelination and virtual hypoxia with high-dose biotin as a treatment for progressive multiple sclerosis. Neuropharmacology. 2015 Sep 5. pii: S0028-3908(15)30073-3. doi: 10.1016/j.neuropharm.2015.08.028. [Epub ahead of print] View Full Article

      SUGGESTED SUPPLEMENTS

      The following supplements are suggested for you to consider in light of your relevant expertise and intimate understanding of the needs of your client or patient. They may be used in isolation or as part of a multi supplement strategy, but at all times the consideration of their use should be tied into the specific needs of the individual you are responsible for.

      B1 + B5 +

      Stamina Caps (BRC) – 2 with breakfast& lunch & 2 at 6 pm – http://tinyurl.com/zxrzumk

      Or

      Thiamin 50 (BRC) – 1-2 with each meal

      Biotin

      HiBiotin (ARG) (100 mg biotin) (ARG) – 1 with breakfast & dinner

       

      There maybe other B vitamins, including Vit B12) which may be worthwhile considering in supplement form based on testing.

       

      Topical Creams

      Capsaicin cream may support the blood supply to the skin. There can be some heat from such creams. Arnica cream may be something to consider.

      It is hoped that something here will be of value to this woman. Do let us know how she gets on.

      Antony

       

       

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